Workshop Organizers:
Fjola Johannesdottir, Harvard Medical School, Boston, USA
Ling Wang, Department of Radiology, Beijing Jishuitan Hospital, Beijing, China
Leon Lenchick, Department of Radiology, Wake Forest University, USA
Klaus Engelke, Department of Medicine III and Institute of Medical Physics, University of Erlangen-Nuremberg, Germany
Workshop Information:
Muscle imaging has always been an integral component in the diagnosis of muscle myopathies but has only recently received more attention in the context of osteoporotic fracture and sarcopenia. It is the aim of this workshop to introduce and discuss CT muscle imaging techniques and applications in an interactive format. The workshop is divided into three sections to address basic topics relevant for participants new to muscle imaging as well as latest research results relevant for those already working in the field. The three sections are
1. Technical Basics: Calibration, Segmentation, Parameters characterizing muscle size, density and fat infiltration Topics are: CT acquisition techniques, muscle calibration – from CT values to muscle density, how to determine muscle density in opportunistic CT scans and the analysis of basic CT muscle biomarkers describing muscle volume, density and fat infiltration.
2. Muscle Radiomics and Applications in Sarcopenia This section will explain the potential of radiomic techniques and to leveraging machine learning-driven automated CT image analysis pipelines. Radiomics constitutes the extraction and analysis of quantitative features from medical images, revealing details beyond human perception and conventional image analysis. These features have enhanced approaches to screening, detection, diagnosis, staging, prognosis, and treatment response prediction in many medical disciplines. Here we will focus on sarcopenia
3. Muscle Assessment to Improve Fracture Risk Evaluation The last part is dedicated to the exciting and highly relevant question whether muscle imaging biomarkers can contribute to the prediction of osteoporotic fracture risk. We will give an overview over published results for prediction of spine and hip fracture risk. We will concentrate on data from larger epidemiological studies such as AGES Reykjavik or China Action on Spine and Hip Status (CASH).
We are looking forward to answering your questions and to discuss your muscle imaging topics – bring examples.
Workshop Organizers:
Ali Ghasem-Zadeh, University of Melbourne, Australia
Steven Boyd, University of Calgary, Canada
Bert van Rietbergen Eindhoven University of Technology, Netherlands
Galateia Kazakia, University of California, San Francisco, USA
Andrew Burghardt, University of California, San Francisco, USA
Workshop Information:
Bone microstructure is complex, undergoing dynamic changes with aging, menopause, and bone-related diseases, and varying significantly across different points and sections of the bone. This complexity necessitates thorough consideration in studying change in bone microstructure utilising high resolution images in the scale of trabecular bone.
High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) has become an essential imaging modality for non-invasive musculoskeletal assessment in humans, offering high-resolution 3D imaging of cortical and trabecular bone. Longitudinal studies, particularly in clinical trials and aging, as well as during growth, provide the opportunity to investigate dynamic physiologic processes at the micro-scale and their relation to biomechanical function and fragility.
However, there are many technical considerations that make the interpretation of longitudinal changes in HR-pQCT outcome measures challenging. Furthermore, a number of novel approaches to evaluating change have been introduced to provide a richer understanding of complex spatiotemporal processes in bone.
In this workshop, we will discuss longitudinal analysis methods for HR-pQCT – exploring both the challenges and opportunities in assessing change in bone structure and strength. Specific topics will include: